2024 Asia Conference on Lung Cancer (ACLC) - Poster & ePosters-EP02.19

EP02.19 - Hanbo Pan

Pdf Summary

This multi-center real-world study involving 7932 Chinese cases evaluates the early outcomes of radical surgery in non-small cell lung cancer (NSCLC) patients with and without a history of COVID-19. The study aimed to determine if a prior COVID-19 infection elevates surgical risks for these patients. Using propensity-score matching, researchers minimized patient selection bias, resulting in 3021 cases each for groups with (POCVD) and without (NCVD) COVID-19 history.<br /><br />The findings demonstrated that, generally, radical resection is safe for Chinese NSCLC patients with past COVID-19 infection. However, the POCVD group experienced longer surgical durations and a higher incidence of postoperative respiratory complications compared to their NCVD counterparts. The mean surgical duration for the POCVD group was significantly longer at approximately 121 minutes compared to 111 minutes for the NCVD group.<br /><br />Older patients (aged ≥70 years) and those with a smoking history emerged as high-risk groups, exhibiting elevated surgical risks and postoperative complications. Specifically, these patients faced increased odds of developing complications graded Clavien-Dindo II, which were characterized by extended surgical durations, increased respiratory issues, longer chest tube drainage times, and extended hospital stays post-operation. The odds ratios indicated a heightened risk of complications for both elderly patients (OR: 1.322) and smokers (OR: 1.235).<br /><br />Overall, the study underscores the importance of careful preoperative evaluation for NSCLC patients with a history of COVID-19, especially those who are older or have a smoking history. These findings could inform surgical decision-making and resource allocation to mitigate risks in vulnerable patient populations.

Keywords

NSCLC

COVID-19

radical surgery

postoperative complications

propensity-score matching

surgical risks

older patients

smoking history

Clavien-Dindo

real-world study