2024 Asia Conference on Lung Cancer (ACLC) - Poster & ePosters-PP01.11

PP01.11 - Yanwei Zhang

Pdf Summary

The study conducted by Yanwei Zhang and colleagues investigates the role of microRNA-125b (miR-125b) in inflammation-related non-small cell lung cancer (NSCLC). Lung cancer is the leading cause of cancer-related deaths worldwide, and despite advancements in treatment, overall survival rates remain inadequate. The research focuses on how chronic inflammation and microRNAs impact cancer progression. <br /><br />The findings reveal that miR-125b expression is significantly reduced in NSCLC cell lines when stimulated by the anti-inflammatory cytokine IL-10, but its levels increase markedly upon stimulation by the pro-inflammatory cytokine IFN-γ. It was observed that artificially increasing miR-125b levels enhances tumor cell proliferation, migration, and invasion while reducing cell apoptosis. Conversely, suppressing miR-125b leads to opposite effects, indicating its role in promoting NSCLC progression. <br /><br />The study identifies Deleted in Azoospermia-associated protein 2 (DAZAP2) as a direct target of miR-125b. Inhibition of miR-125b along with DAZAP2 showed a notable synergistic effect in reducing tumor growth in both laboratory and live models. <br /><br />These results underscore miR-125b and DAZAP2 as promising therapeutic targets for treating NSCLC, especially in cases linked with chronic inflammation. This research was conducted by the Department of Pulmonary Medicine at Shanghai Chest Hospital, part of Shanghai Jiaotong University School of Medicine, highlighting the potential for developing novel treatment strategies targeting these molecules to improve outcomes for NSCLC patients.

Keywords

microRNA-125b

NSCLC

inflammation

lung cancer

IL-10

IFN-γ

DAZAP2

tumor progression

therapeutic targets

Shanghai Jiaotong University