2024 Asia Conference on Lung Cancer (ACLC) - Poster & ePosters-PP01.18

PP01.18 - John Kay Hooi Ang

Pdf Summary

The document outlines the creation and application of a prospective lung cancer database at the Department of Medical Oncology in Tan Tock Seng Hospital (TTSH), Singapore, launched in 2022. This database, part of a broader oncology service expansion across three National Healthcare Group hospitals—including TTSH, KTPH, and WHC—aims to analyze clinical features, molecular profiles, and treatment outcomes for cancer patients.<br /><br />By August 2024, the database had registered 840 patients across various cancer types, with lung/thoracic malignancies making up 24.5% of cases. The data collection involves patient demographics, tumor types, molecular profiling, diagnostics, treatment processes, and outcomes, all logged electronically and anonymously.<br /><br />The document highlights the prevalence of different thoracic malignancies, noting that non-small cell lung cancer (NSCLC), especially adenocarcinoma, predominates. Small cell lung cancer is also discussed, with data showing use of chemotherapy and immunotherapy combinations based on disease stage.<br /><br />The findings from the database underline significant aspects of molecular profiling for NSCLC, where 70.1% of the lung adenocarcinoma patients presented with targetable molecular alterations, key among them EGFR mutations and other mutations like ALK and ROS1.<br /><br />The document also discusses first-line systemic treatment regimens, noting the application of osimertinib for EGFR mutations, and other treatments for various mutations. The prospective database serves as a tool for improving treatment outcomes and guiding clinical practices through real-world evidence. It is positioned to enhance collaborative research and support international clinical trials, thus broadening the scope of TTSH's oncology services across central and northern Singapore. The ultimate goal is to improve clinical services in the NHG cluster, leveraging the database for comprehensive insights into cancer characteristics and patient outcomes.

Keywords

lung cancer database

Tan Tock Seng Hospital

oncology service expansion

molecular profiling

NSCLC

EGFR mutations

osimertinib

chemotherapy

immunotherapy

clinical trials