2024 Asia Conference on Lung Cancer (ACLC) - Poster & ePosters-PP01.23

PP01.23 - Chiaki Kanno

Pdf Summary

The study presented investigates the incidence and risk factors associated with post-operative acute exacerbation of interstitial pneumonia (IPAE) in patients with surgically resected lung cancer complicated by interstitial pneumonia (IP). Conducted at the Kanagawa Cancer Center in Japan, the research assessed various patient characteristics and surgical approaches, focusing on outcomes and potential prevention strategies for IPAE.<br /><br />Key findings indicate that IPAE is a significant cause of post-operative mortality in these patients, with an incidence of 18% and a mortality rate of 91% observed in this study. This is notably higher than the 9.3% incidence and 43.9% mortality reported in previous multicenter studies. The study highlights that patients with a forced vital capacity (%VC) less than 80 or those undergoing more extensive procedures like lobectomy are at higher risk. Segmentectomy might be more beneficial, as it showed a lower incidence of IPAE compared to lobectomy.<br /><br />The study underscores the need for careful surgical candidate selection and management strategies. Prevention protocols, including the use of clarithromycin and methylprednisolone, were utilized to potentially mitigate the risk of exacerbations.<br /><br />The results suggest re-evaluating surgical indications and perioperative care for patients with IP, focusing on individualized treatments to reduce the risk of IPAE. The insights emphasize the need for a strategic approach in the surgical management of lung cancer patients with interstitial pneumonia, with possible benefits from less invasive surgical techniques like segmentectomy for high-risk individuals.

Keywords

post-operative acute exacerbation

interstitial pneumonia

lung cancer surgery

risk factors

mortality rate

forced vital capacity

lobectomy

segmentectomy

prevention strategies

perioperative care