2024 Asia Conference on Lung Cancer (ACLC) - Poster & ePosters-PP01.28

PP01.28 - Xue He

Pdf Summary

This retrospective cohort study explores the relationship between acetaminophen exposure and 28-day mortality in critically ill patients with primary lung cancer. Conducted by Xue He and Chen Chen from the Department of Thoracic Surgery at The Second Xiangya Hospital of Central South University, the study utilizes data from the MIMIC-IV v2.2 database, comprising 1,140 critical patients with primary lung cancer. This research addresses the previously unclear connection between acetaminophen use and mortality outcomes in this patient cohort.<br /><br />Key outcomes indicate that 28-day mortality is significantly lower in patients exposed to acetaminophen compared to those who were not. The mortality rate was 38% among those with no acetaminophen exposure, versus 21.9% for those who received the drug. Thorough statistical analysis, including Cox regression and Kaplan-Meier survival curves, confirms the association of reduced mortality with acetaminophen administration, showing a hazard ratio (HR) of 0.69, with a 95% confidence interval of 0.55 to 0.88 and p-value of 0.002.<br /><br />The benefits of acetaminophen extend to secondary outcomes as well, including reductions in ICU, in-hospital, 30-day, 90-day, and 365-day mortality rates. Subgroup analyses, adjusted for various confounders, consistently support these findings.<br /><br />The study concludes that acetaminophen administration is associated with lower 28-day mortality rates in critically ill patients with primary lung cancer. However, the authors emphasize the need for randomized controlled trials to establish causal relationships. The study was supported by the National Natural Science Foundation of China and other health research projects.<br /><br />Overall, this study provides valuable insights into potential therapeutic benefits of acetaminophen in reducing short-term mortality among critically ill lung cancer patients, calling for further investigation to validate these findings.

Keywords

acetaminophen

28-day mortality

critically ill patients

primary lung cancer

MIMIC-IV database

Cox regression

Kaplan-Meier survival curves

hazard ratio

randomized controlled trials

National Natural Science Foundation of China