2024 Asia Conference on Lung Cancer (ACLC) - Poster & ePosters-PP01.30

PP01.30 - Abe Kohei

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The study aimed to explore the relationship between smoking habits and histopathological subtypes of lung adenocarcinoma in patients who underwent surgery. The research analyzed 1,640 cases from 2004 to 2023, categorizing smokers based on the Brinkman Index (BI) into four groups. The primary focus was on demonstrating how smoking may influence the histological subtypes of lung adenocarcinoma.<br /><br />Results indicated that out of the five major subtypes—papillary, lepidic, acinar, solid, and micropapillary—the solid subtype was notably more prevalent among smokers, with its incidence increasing alongside higher Brinkman Index scores. Conversely, the lepidic subtype was more frequently observed in nonsmokers. The association persisted across both male and female smokers.<br /><br />As smoking increased, the proportion of the solid subtype rose, while the lepidic subtype decreased, suggesting smoking's significant role in promoting the development of the solid subtype. Genetic mutations and cell proliferation driven by smoking are postulated mechanisms, though detailed pathways remain unclear. <br /><br />The study concluded that smoking correlates with a higher incidence of more aggressive subtypes like the solid subtype of lung adenocarcinoma. This information can be crucial for clinicians in risk assessment and designing tailored interventions for lung adenocarcinoma patients based on their smoking history.

Keywords

smoking habits

lung adenocarcinoma

histopathological subtypes

Brinkman Index

solid subtype

lepidic subtype

genetic mutations

cell proliferation

risk assessment

tailored interventions