2024 Asia Conference on Lung Cancer (ACLC) - Poster & ePosters-PP01.35

PP01.35 - Yuan Xu

Pdf Summary

The study investigates the role of DERL3, a protein pivotal in degrading misfolded lumenal glycoproteins during endoplasmic reticulum stress, in lung adenocarcinoma (LUAD). Researchers aim to clarify the unclear association between DERL3 expression and LUAD cells. Clinical samples were analyzed for DERL3 mRNA and protein expressions using RT-qPCR and immunohistochemistry. Online tools GEPIA and TIMER were employed to examine DERL3's correlation with immune cell infiltration, and a t-distributed stochastic neighbor embedding (t-SNE) map was utilized to visualize DERL3’s distribution at the single-cell level. Additionally, biological processes mediated by DERL3 in LUAD were explored through KEGG and GSEA analyses.<br /><br />Results demonstrated that DERL3 levels were significantly higher in LUAD tissues compared to adjacent normal tissues. Furthermore, DERL3 was notably linked to immune infiltration, particularly within plasma cells of the B cell population. This suggests an association between DERL3 expression and immune system interactions within the tumor environment. The study also identified a ZC3H12D-hsa-miR-4443-ENST00000630242 ceRNA network in LUAD, indicating ZC3H12D's role in patient prognosis by modulating various types of RNA, immune cells, and immune molecules.<br /><br />Overall, the study concluded that DERL3 is predominantly associated with B cell activation and the unfolded protein response (UPR) in LUAD, revealing potential targets for therapeutic intervention and improved prognosis strategies. The findings underscore the importance of DERL3 in the pathology of LUAD, offering insights into its linkage to immune features and potential as a biomarker for disease progression.

Keywords

DERL3

lung adenocarcinoma

LUAD

immune infiltration

B cells

unfolded protein response

biomarker

ZC3H12D

ceRNA network

therapeutic targets