2024 Asia Conference on Lung Cancer (ACLC) - Poster & ePosters-PP01.37

PP01.37 - Anand Sachithanandan

Pdf Summary

The study titled "Genomic Landscape for Resectable Early Non-Small Cell Lung Cancer in Malaysia" was a retrospective observational analysis involving 96 consecutive patients who underwent Next Generation Sequencing (NGS) testing and curative surgical lobectomy for primary Non-Small Cell Lung Cancer (NSCLC). Conducted between January 2021 and February 2024 at two major tertiary hospitals in Malaysia, the research aimed to address the limited prevalence data on oncogenic driver mutations in early resectable NSCLC within the country.<br /><br />Key findings from the study included the high prevalence of druggable mutations, particularly EGFR and ALK mutations, which underscores the necessity for early genomic profiling to adopt biomarker-driven treatment strategies effectively. The study's results emphasized the importance of incorporating genomic profiling at initial diagnosis, especially in the current era focusing on peri-operative immunotherapy and oral targeted therapies.<br /><br />Among patients with EGFR mutations, 53% displayed mutations in exon 19 and exon 21. Moreover, 20.3% of the patients had co-mutations, notably involving the TP53 gene. The study also observed that never-smokers, those with adenocarcinoma, and asymptomatic patients had notable predictors of EGFR mutations.<br /><br />The research highlights a comprehensive genomic landscape assessment for NSCLC patients in Malaysia, offering critical insights that could guide future therapeutic approaches. It advocates for integrating genomic data into patient management to optimize treatment outcomes for NSCLC patients, particularly in regions with previously limited mutation prevalence data.<br /><br />The study was conducted by various departments from the Subang Jaya Medical Centre and Sunway Medical Centre, emphasizing collaboration across cardiothoracic surgery and pathology departments to enhance the understanding of NSCLC's genetic underpinnings in Malaysia.

Keywords

Genomic Landscape

Non-Small Cell Lung Cancer

Malaysia

Next Generation Sequencing

EGFR mutations

ALK mutations

TP53 gene

adenocarcinoma

biomarker-driven treatment

genomic profiling