2024 Asia Conference on Lung Cancer (ACLC) - Poster & ePosters-PP01.48

PP01.48 - Yuan Xu

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The research conducted by Yuan Xu and colleagues at the Second Affiliated Hospital of Fujian Medical University focuses on the prognostic implications of the competing endogenous RNA (ceRNA) network in stage I lung adenocarcinoma (LUAD). Utilizing data from The Cancer Genome Atlas (TCGA), the study identifies and analyzes the roles of key RNA elements. The researchers obtained 1,955 differentially expressed mRNAs (DEmRNAs), 165 differentially expressed miRNAs (DEmiRNAs), and 1,107 differentially expressed lncRNAs (DElncRNAs), constructing a network consisting of 8,912 lncRNA-miRNA-mRNA pairs. <br /><br />Their analysis identified the ME turquoise module as significantly linked to LUAD progression through Weighted Gene Co-expression Network Analysis (WGCNA). The study particularly highlights the pivotal role long non-coding RNAs (lncRNAs) play in the tumorigenesis and metastasis of lung cancer. By characterizing the lncRNA-associated ceRNA network, the study aims to pinpoint lncRNAs crucial for stage I LUAD development.<br /><br />Three lncRNAs—LINC00639, RP4-676L2.1, and FENDRR—were found integral to the ceRNA network. Among these, FENDRR emerged as a noteworthy risk factor concerning progression-free survival (PFS) of stage I LUAD patients, as revealed through univariate Cox regression analysis (HRs 1.69, 95% CI 1.07–2.68, P<0.050). Furthermore, FENDRR's differential expression in both normal and LUAD tissues was confirmed as significant via real-time quantitative PCR (qRT-PCR) (P<0.001).<br /><br />The study uncovers the FENDRR/miR-6815-5p axis's regulatory role in early-stage LUAD progression, suggesting a novel pathway influencing the disease's advancement, which requires further verification through in vitro and in vivo studies. This research provides valuable insights for future prognostic assessments and therapeutic strategies targeting early-stage lung adenocarcinoma.

Keywords

ceRNA network

stage I lung adenocarcinoma

prognostic implications

FENDRR

lncRNAs

Weighted Gene Co-expression Network Analysis

LINC00639

RP4-676L2.1

The Cancer Genome Atlas

early-stage LUAD progression