2024 Asia Conference on Lung Cancer (ACLC) - Poster & ePosters-PP01.54

PP01.54 - Mansi Sharma

Pdf Summary

The study titled "ACCESS: Assessing Clinical Care Experience in Implementation of Precision Medicine: A Single Center Study" conducted by researchers from the Rajiv Gandhi Cancer Institute and Research Centre and the FORTIS Memorial Research Institute aims to evaluate precision medicine practices for Non-Small Cell Lung Cancer (NSCLC) patients. It focuses on biomarker testing from 2014 to 2023, aligning with IASLC/AMP 2018 recommendations.<br /><br />During the study period, 6,400 NSCLC patients were registered, with a male-to-female ratio of approximately 2.2:1 and a median age of 67. NGS testing for biomarkers increased significantly post-2018 mandate—from 11% initially to 74% by 2023, with notable annual progress and a peak increase of 51% in 2022. NGS testing, compared to single gene testing, identified 37.8% more cases involving actionable biomarkers and showed improvements of 10.2% in EGFR detection, with some reductions in ALK detection.<br /><br />The study also analyzed the uptake of targeted therapies following biomarker detection, revealing variability across different mutations. While targeted therapy was more consistently implemented for mutations like EGFR and ALK, KRAS G12C mutation cases did not receive selective treatments due to drug unavailability.<br /><br />Overall, this research highlights the increased adoption of precision medicine technologies like NGS testing over time, fueled by greater clinical awareness and cost-effective indigenous solutions. However, challenges remain in aligning treatments with molecular test results. The study provides substantial real-world evidence from a single center in India, underscoring the need to bridge identified clinical gaps. Correspondence for the study can be directed to Ullas Batra via email.

Keywords

precision medicine

NSCLC

biomarker testing

NGS testing

EGFR detection

ALK detection

KRAS G12C mutation

targeted therapy

clinical gaps

India