2024 Asia Conference on Lung Cancer (ACLC) - Poster & ePosters-PP01.61

PP01.61 - Yupeng Di

Pdf Summary

Primary pulmonary lymphoepithelioma-like cancer (PPLELC) is a rare form of lung cancer with limited available data guiding treatment decisions. The study aimed to assess the impact of surgical intervention on overall survival (OS) and cancer-specific survival (CSS) in patients diagnosed with PPLELC. <br /><br />Researchers utilized a population-based database, specifically the SEER database, to identify patients with PPLELC and evaluate the effects of surgical treatment. The study included 86 patients, 21 of whom underwent surgery, while the remaining 65 did not. The researchers employed univariate Kaplan-Meier analyses and multivariate Cox proportional hazards regression models to analyze the data and determine the influence of surgery on survival outcomes.<br /><br />The study found that surgery offers a significant survival benefit for PPLELC patients, impacting both OS and CSS positively. Certain clinicopathological factors, such as age, were identified as independent prognostic factors affecting the survival of patients. The findings underscore the potential role of surgery as a critical component in managing this unique subtype of non-small-cell lung cancer (NSCLC).<br /><br />Given the rarity of the disease and the paucity of randomized clinical trials, the study provides valuable insights into the potential benefits of surgical intervention for PPLELC. This information can help guide treatment decisions and optimize patient outcomes, although more research is necessary to further validate these findings.<br /><br />In conclusion, while PPLELC remains a rare and under-researched lung cancer subtype, surgical treatment is highlighted as a viable option in improving survival rates, offering critical guidance for clinicians managing such cases.

Keywords

Primary pulmonary lymphoepithelioma-like cancer

PPLELC

lung cancer

surgical intervention

overall survival

cancer-specific survival

SEER database

Kaplan-Meier analyses

Cox proportional hazards

non-small-cell lung cancer