2024 Asia Conference on Lung Cancer (ACLC) - Poster & ePosters-PP01.80

PP01.80 - Keyu Zhu

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The document describes a study investigating the genetic connections between three subtypes of lung carcinoma (lung adenocarcinoma, squamous cell lung carcinoma, and small cell lung carcinoma) and chronic pain, aiming to uncover shared genetic architectures that could explain comorbidity. Using linkage disequilibrium score regression (LDSC) and genome-wide analysis studies (GWAS), the research identified potential shared functional genes in lung tissue. Specific attention was given to the role of SUOX (sulfite oxidase), a gene proposed to influence chronic pain and small cell lung carcinoma (SCLC).<br /><br />The study demonstrated that SUOX might be a key mediator in the relationship between chronic pain and lung cancer, particularly SCLC. Experimental procedures such as CCK8 assays and Annexin-V FITC/PI analysis were used to assess SUOX's impact on tumor cell apoptosis. Results showed that inhibiting SUOX could induce mitochondrial membrane swelling and decrease mitochondrial membrane potential, leading to cell death.<br /><br />Through mechanistic investigations using western blotting, it was found that SUOX inhibition significantly affected the mitochondrial apoptosis pathway, altering protein levels of cleaved caspase-3, cleaved caspase-9, Cyto-C, Bax, and Bak. This provided evidence that genetic overlap between chronic pain and lung cancer could facilitate tumorigenesis and immune escape, suggesting that targeting SUOX might offer therapeutic potential for managing SCLC and associated chronic pain.<br /><br />Overall, the research highlights a novel genetic link between chronic pain and lung cancer and suggests avenues for future therapeutic strategies that could address both conditions simultaneously.

Keywords

lung carcinoma

chronic pain

genetic connections

linkage disequilibrium score regression

genome-wide analysis studies

SUOX gene

mitochondrial apoptosis

tumorigenesis

immune escape

therapeutic strategies