2024 Asia Conference on Lung Cancer (ACLC) - Poster & ePosters-PP02.14

PP02.14 - Takashi Inoue

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This study, conducted by Dokkyo Medical University, investigates prognostic factors associated with poor outcomes in patients undergoing induction therapy for advanced non-small cell lung cancer (NSCLC) in Japan. Despite the introduction of immune checkpoint inhibitor (ICI) therapy, chemoradiotherapy remains the standard preoperative treatment for stage IIIA NSCLC. This research aims to understand prognostic factors by analyzing outcomes of conventional induction therapy.<br /><br />The study involves 158 patients treated at the university's hospital from January 2001 to December 2022. Among these, 143 received chemoradiation therapy and 10 solely chemotherapy. Induction therapies included chemotherapy combinations and targeted therapy with gefitinib. The cohort consisted of 120 males and 38 females with an average age of 69.4 years, predominantly in stages IIIA and IIIB.<br /><br />Key findings identified factors contributing to poor prognosis, including a high residual tumor rate (50%), absence of postoperative therapy, and non-adenocarcinoma nonsquamous histology. The analysis utilized the Kaplan-Meier method to calculate survival outcomes, revealing significant differences based on these factors. Residual tumor rate over 50% significantly decreased the 5-year recurrence-free survival (RFS) and overall survival (OS). Patients with postoperative therapy showed improved RFS and OS compared to those without.<br /><br />Furthermore, non-adeno nonsquamous carcinoma presented zero survival rates at five years, underscoring its poor prognosis compared to adenocarcinoma and squamous cell carcinoma types.<br /><br />This research highlights important prognostic indicators that could influence treatment strategies for advanced NSCLC, emphasizing the need for postoperative therapies and the impact of histological subtypes on survival outcomes. The study was presented at the 2024 Asia Conference on Lung Cancer, with the authors declaring no conflicts of interest.

Keywords

Dokkyo Medical University

prognostic factors

non-small cell lung cancer

induction therapy

chemoradiotherapy

immune checkpoint inhibitor

residual tumor rate

postoperative therapy

Kaplan-Meier method

histological subtypes