2024 Asia Conference on Lung Cancer (ACLC) - Poster & ePosters-PP02.40

PP02.40 - Ying-Long Peng

Pdf Summary

The study investigates the impact of smoking history on the efficacy of immunotherapy for lung cancer patients, revealing varying influences at different treatment stages. Conducted by researchers from Guangdong Provincial People’s Hospital and other institutions, the study utilized time-dependent Cox regression analyses on data collected from the hospital. Findings indicate that smoking history significantly affects progression-free survival (PFS) in lung cancer immunotherapy patients. <br /><br />Current smokers served as the reference group in the analysis. Results showed that both former smokers (HR: 1.52; 95% CI: 1.05-2.19) and never smokers (HR: 3.25; 95% CI: 2.18-4.85) exhibited shorter PFS compared to current smokers. However, when examining PFS specifically, never smokers had a notably worse outcome than current smokers in the early stages, for those with PFS under 6 months (HR: 4.31; 95% CI: 2.50-7.43). In contrast, never smokers showed better outcomes over longer periods, with longer PFS than current smokers in periods beyond 14.1 months (HR: 0.45; 95% CI: 0.20-0.97).<br /><br />These findings highlight the changing influence of smoking history at different points during immunotherapy treatment. While initially detrimental, never smoking appears to provide benefits over the long-term. The study underscores the importance of considering smoking history and timing in the analysis of lung cancer immunotherapy efficacy. The researchers adjusted for various factors, including sex, age, gene variants, PD-L1 expression, cancer stage, and treatment specifics, to ensure comprehensive results. These insights contribute to the nuanced understanding of how lifestyle factors like smoking history can shape treatment outcomes in oncology.

Keywords

smoking history

immunotherapy

lung cancer

progression-free survival

Cox regression

current smokers

former smokers

never smokers

treatment stages

oncology outcomes