2024 Asia Conference on Lung Cancer (ACLC) - Poster & ePosters-PP02.52

PP02.52 - Xiaojun Wang

Pdf Summary

This multicenter, retrospective study led by Xiaojun Wang and Yongde Liao compared two treatment strategies for unresectable stage III non-small cell lung cancer (NSCLC): surgery following immunochemotherapy and chemoradiotherapy followed by immunotherapy. The standard treatment for this condition typically involves concurrent chemoradiotherapy followed by consolidation immunotherapy. However, recent clinical practices have started incorporating conversion surgery post-downstaging through immunochemotherapy as an alternative.<br /><br />The study analyzed data from March 2019 to April 2022 across three medical centers, involving 108 patients divided into two groups: 59 in the CIOT surgery group, treated with induction immunochemotherapy followed by conversion surgery, and 49 in the CRTIO group, treated with concurrent/sequential chemoradiotherapy followed by consolidation immunotherapy. The researchers used Kaplan-Meier analysis to compare overall survival (OS) and progression-free survival (PFS) between the groups.<br /><br />Findings revealed that the CIOT surgery group had a 30-month OS rate of 80.8% and a PFS rate of 68.6%. Meanwhile, the CRTIO group had a 30-month OS rate of 70.3% and a PFS rate of 41.2%. Although the CIOT surgery group demonstrated a longer PFS, there was no significant difference in overall survival compared to the CRTIO group.<br /><br />In conclusion, the study suggests that conversion surgery post-immunochemotherapy is not inferior to the traditional chemoradiotherapy followed by immunotherapy regimen. This could position conversion surgery as a viable alternative treatment option for patients with initially unresectable stage III NSCLC, offering potentially better progression-free survival outcomes without adversely affecting overall survival.

Keywords

unresectable stage III NSCLC

immunochemotherapy

chemoradiotherapy

conversion surgery

progression-free survival

overall survival

Kaplan-Meier analysis

Xiaojun Wang

Yongde Liao

multicenter retrospective study