2024 Latin America Conference on Lung Cancer (LALCA) - Posters-PP01.07: Challenges in Molecular Testing in Non-Small Cell Lung Cancer (NSCLC) in Argentina. General Pathologist Real World Perspective

PP01.07: Challenges in Molecular Testing in Non-Small Cell Lung Cancer (NSCLC) in Argentina. General Pathologist Real World Perspective

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The document highlights the challenges faced by general pathologists in Argentina when conducting molecular testing for non-small cell lung cancer (NSCLC). It notes that pathology labs across the country vary in their capacity and access to advanced testing techniques such as immunohistochemistry, with molecular testing services being centralized in only a few sophisticated labs.<br /><br />A survey initiated by the Argentinian Society of Pathologists revealed several insights, with 110 pathologists participating, showcasing knowledge gaps and the variable involvement of pathologists in molecular testing for lung cancer. Notable findings include that 24% of pathologists are unfamiliar with associated molecular tests, while 61% expressed a desire for more information, having received none before. Additionally, pathology practices in Argentina are largely split between public and private institutions. A significant portion of pathologists receive only a small number of lung cancer samples monthly.<br /><br />The survey found that molecular testing requests typically come from oncologists rather than pathologists, with fewer than 12% of pathologists performing reflex testing internally. Most depend on external facilities for these tests, and only 20% receive biomarker test results. Furthermore, interdisciplinary meetings on lung cancer patient cases see limited pathologist involvement, with only 39% participating.<br /><br />Pre-analytical handling of samples, including biopsy processing and specimen fixation, varies significantly across labs. Challenges include the timing of specimen fixation and the type of fixatives used, affecting the quality and reliability of testing.<br /><br />The study concludes that there's a pronounced need for educational initiatives to bridge knowledge gaps, especially in remote or less equipped areas, thus fostering better integration of pathologists in NSCLC molecular testing.

Asset Subtitle

Maria Emilia Rodriguez

Keywords

pathologists

Argentina

molecular testing

non-small cell lung cancer

NSCLC

immunohistochemistry

biomarker

oncologists

educational initiatives

specimen fixation