2024 Latin America Conference on Lung Cancer (LALCA) - Posters-PP01.13: Lung Resections for Non-Small Cell Lung Cancer in ‘Young Adults’: Excellent Prognosis and Other Clinicopathologic Features of 43 Cases

PP01.13: Lung Resections for Non-Small Cell Lung Cancer in ‘Young Adults’: Excellent Prognosis and Other Clinicopathologic Features of 43 Cases

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This study investigates the characteristics and prognosis of young adults aged 18-45 who underwent lung resection for non-small cell lung cancer (NSCLC) at Harefield and Royal Brompton Hospitals from January 2013 to December 2023. Lung cancer remains a major cause of mortality, and its occurrence in younger adults is on the rise, presenting unique prognostic features.<br /><br />The retrospective review included 43 patients (25 females and 18 males) with a mean age of 40. The majority underwent lobectomies (74.4%), with almost equal distribution between thoracotomy (53.5%) and minimally invasive surgery (46.5%). The median hospital stay was 5 days. The tumors had an average size of 32 mm, with 32.6% showing pleural invasion. Staging revealed that 62% were in stages 1-2, and 31% were in stages 3-4.<br /><br />Smoking history revealed that 55.8% had never smoked, while 44.2% were active or ex-smokers. Molecular testing showed a varied presence of genetic mutations, with 28% testing positive for EGFR and 20% for ROS. PD-L1 expression was present in all tested cases, with varying scores indicating levels of expression.<br /><br />Survival analysis using the Kaplan-Meier method indicated an excellent 5-year overall survival rate of 88%, with early-stage (1-2) and advanced-stage (3-4) patients having survival rates of 91% and 80% respectively. However, there was no statistically significant difference in survival between the two groups.<br /><br />The study concludes that young adults have an excellent prognosis following lung resections for NSCLC. It highlights the importance of integrating molecular testing and multimodal treatment approaches to optimize patient outcomes.

Asset Subtitle

Murat Kapdagli

Keywords

young adults

lung resection

non-small cell lung cancer

NSCLC

prognosis

molecular testing

surgery

survival rate

genetic mutations

Kaplan-Meier method