2024 Targeted Therapies for Lung Cancer (TTLC) - Abstracts & Posters-PP01.20 Huang

PP01.20 Huang - Poster

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This study conducted by researchers at Icahn School of Medicine at Mount Sinai in New York assessed the risk of developing second primary lung cancer (LC) in women who have previously had breast cancer (BC). The analysis focused on women aged 54 to 75 from the PLCO screening trial conducted between 1993 and 2017. The study utilized Poisson methods to calculate incidence rate ratios for LC among BC survivors compared to females without a history of BC, adjusting for various factors such as age, education, smoking history, and BMI. The findings revealed that BC survivors had a 27% increased risk of developing second primary LC compared to non-BC survivors. Additionally, the study highlighted the importance of individualized eligibility assessments for LC screening among BC survivors and suggested the need for further research to determine optimal screening approaches to maximize benefits while minimizing harm. Notably, current smokers were found to have a significantly higher risk of developing LC. The unadjusted incidence rate of LC among BC survivors was 191.7 per 100,000 person-years, compared to 143 per 100,000 person-years among non-BC survivors. The study emphasizes the importance of understanding the risk factors and implications of second primary cancers in BC survivors, particularly focusing on LC prevention and screening strategies tailored to this population.

Keywords

lung cancer

breast cancer survivors

second primary cancer

risk assessment

Poisson methods

incidence rate ratios

screening trial

smoking history

individualized eligibility assessments

LC prevention