2024 World Conference on Lung Cancer (WCLC) - Posters-P1.01A.02 Monitoring Inflammatory Response Secondary to Air Pollution Exposure Through Volatile Organic Compounds

P1.01A.02 Monitoring Inflammatory Response Secondary to Air Pollution Exposure Through Volatile Organic Compounds

Pdf Summary

The study investigates the inflammatory response triggered by exposure to air pollution through volatile organic compounds (VOCs) in exhaled breath, using a randomised, double-blind crossover, controlled trial. Nineteen healthy, non-smoking adults participated, undergoing two separate exposures—diesel exhaust (DE) with 300μg/m3 of PM2.5 and filtered air (FA) as a control—in an exposure booth at the APEL lab, four weeks apart. Breath samples were collected and analyzed using the Breath Biopsy device before, immediately after, and at various intervals up to 24 hours post-exposure. Blood samples were concurrently assessed at key time points for inflammatory markers, including CRP, TNFα, and 8-isoprostane.<br /><br />The study demonstrated that a specific multi-VOC profile in breath could detect inflammation caused by a brief and intense exposure to PM2.5 from diesel fuel. Compounds linked to inflammation, such as hexadecane and butanal, significantly rose in participants’ breath following DE exposure compared to FA. The findings suggest that VOCs in exhaled breath offer a potential non-invasive method to monitor and detect acute airway inflammation caused by air pollution. However, the VOC and blood marker changes observed reverted to baseline levels within 24 hours post-exposure, indicating the temporary nature of the response.<br /><br />Data analysis utilized both univariate and multivariate methods, including linear mixed models, principal component analysis, and ANOVA simultaneous component analysis (ASCA), which revealed significant differences between the exposure types and interactions over time. This research underscores the potential of using VOC analysis as a tool for understanding, monitoring, and perhaps managing respiratory diseases and conditions influenced by air pollution.

Asset Subtitle

Renelle Myers

Meta Tag

Speaker Renelle Myers

Topic Risk Factors, Risk Reduction & Tobacco Control

Keywords

inflammatory response

air pollution

volatile organic compounds

randomised controlled trial

diesel exhaust

PM2.5

Breath Biopsy

inflammatory markers

VOC analysis

respiratory diseases