2024 World Conference on Lung Cancer (WCLC) - Posters-P1.01B.03 Risk Factors Associated with Venous Thromboembolism in Advanced ALK Rearranged Non-Small Cell Lung Cancer

P1.01B.03 Risk Factors Associated with Venous Thromboembolism in Advanced ALK Rearranged Non-Small Cell Lung Cancer

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This document details a retrospective study at the Karolinska University Hospital investigating the risk of venous thromboembolism (VTE) in patients with advanced anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC). The study highlights the increased risk of VTE in this patient group, which is three to five times higher than in other NSCLC variants, suggesting prophylactic anticoagulation could be beneficial.<br /><br />The study analyzed 98 patients treated between January 2009 and December 2021, identifying several risk factors for VTE. Among these patients, 36.7% developed VTE, with the majority being pulmonary. Of concern, the presence of adrenal metastasis, a high body mass index (BMI ≥ 35 kg/m²), elevated leukocyte count (≥ 11x10⁹/L), and low hemoglobin levels (≤ 10g/dL) were associated with significantly higher risks of developing VTE. Conversely, an albumin level of ≥ 3.5g/dL appeared to decrease the risk.<br /><br />The data also showed noteworthy impacts on survival outcomes. Median overall survival (OS) was drastically reduced in patients who developed VTE, with those affected at diagnosis experiencing the most significant decrease, indicating the immediate impact of VTE on survival.<br /><br />The research underlines the potential necessity of prophylactic anticoagulation for these patients due to their heightened risk of cancer-related thrombosis. However, the authors stress the importance of further studies to validate these findings before widespread clinical implementation.<br /><br />This study provides valuable insights into the risk factors and outcomes associated with VTE in ALK-positive NSCLC patients and emphasizes the urgency of further research in this domain to improve patient care and survival outcomes.

Asset Subtitle

Simon Ekman

Meta Tag

Speaker Simon Ekman

Topic Risk Factors, Risk Reduction & Tobacco Control

Keywords

venous thromboembolism

ALK-positive NSCLC

Karolinska University Hospital

prophylactic anticoagulation

adrenal metastasis

body mass index

leukocyte count

albumin level

overall survival

cancer-related thrombosis