2024 World Conference on Lung Cancer (WCLC) - Posters-P1.03C.01 A Landscape of the Driver Alterations in 920 Brazilian Lung Cancer Patients.

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The study focuses on understanding the molecular profile of non-small cell lung cancer (NSCLC) in a cohort of 920 Brazilian patients. Lung cancer is a leading cause of cancer-related deaths globally. Although targeted therapies have transformed treatment, there is limited molecular data for mixed-ancestry populations like Brazil. The research team from various Brazilian institutions, alongside international collaborators, conducted comprehensive genetic analyses.<br /><br />Utilizing next-generation sequencing, the study identified that 88.4% of the patients harbored at least one driver mutation. The common mutations found included EGFR, KRAS, TP53, and ALK fusions, which correlated significantly with patients' smoking history, gender, and ancestry. Notably, EGFR mutations were prevalent among female patients who never smoked and had a non-squamous histology. In contrast, KRAS mutations were more common in ever-smokers with adenocarcinoma. The study also highlights the association of TP53 mutations with males, ever-smokers, those of squamous histology, and patients with higher African ancestry.<br /><br />The overall survival (OS) analysis revealed that patients with EGFR mutations had improved survival rates, while those with TP53 mutations exhibited shorter OS. Interestingly, co-occurrence of EGFR and TP53 mutations led to poorer outcomes with targeted kinase inhibitor (TKI) treatments compared to cases with only EGFR mutations.<br /><br />The research underscores the importance of molecular profiling in NSCLC management, particularly for diverse admixture populations like Brazil. The genetic ancestry analysis reported a majority European heritage among the Brazilian cohort, mixed with African, Native American, and Asian ancestry components.<br /><br />Overall, the study suggests that genetic variability, such as co-occurring mutations, can influence patient outcomes, necessitating tailored therapeutic approaches.

Asset Subtitle

Flávio Augusto Ferreira da Silva

Meta Tag

Speaker Flávio Augusto Ferreira da Silva

Topic Tumor Biology – Translational Biology

Keywords

non-small cell lung cancer

NSCLC

molecular profile

Brazilian patients

next-generation sequencing

driver mutations

EGFR

KRAS

TP53

genetic ancestry