2024 World Conference on Lung Cancer (WCLC) - Posters-P1.03C.02 Different STK11 Mutation Status Defines Various TIME in NSCLC

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The study investigates the impact of STK11 mutations and expression levels on the tumor immune microenvironment (TIME) and survival rates in non-small cell lung cancer (NSCLC), specifically focusing on lung adenocarcinoma (LUAD) compared to lung squamous cell carcinoma (LUSC). Utilizing immunohistochemistry (IHC) and data from the TCGA database, researchers analyzed tissue samples from 188 NSCLC patients to classify them by STK11 expression (STK11High and STK11Low) and mutation status (STK11Mut and STK11Wt). Survival analysis highlighted that low STK11 expression and presence of STK11 mutations correlate with poor prognosis in NSCLC.<br /><br />Analysis revealed that seven immune-related genes were overexpressed in patients with STK11 mutations. Additionally, differences in tumor-infiltrating immune cells were noted mainly in LUAD rather than LUSC.<br /><br />The study suggests that STK11 functions as a protective factor, with its mutation serving as a risk component for NSCLC. The findings propose that alterations in immune-related genes may explain changes in the immune microenvironment, particularly in LUAD, warranting further investigation. <br /><br />This research points toward potential clinical translation; it raises questions about the mechanisms by which immune-related genes influence immune cell infiltration and the possibility of targeting STK11 mutations for therapeutic interventions. Further clinical strategies and treatments might focus on these genetic and immune profiles to improve NSCLC patient outcomes. The study is part of ongoing efforts to understand tumor biology and optimize NSCLC treatments at Fujian Medical University and is backed by specific regional research grants.

Asset Subtitle

Xiaohui Chen

Meta Tag

Speaker Xiaohui Chen

Topic Tumor Biology – Translational Biology

Keywords

STK11 mutations

tumor immune microenvironment

non-small cell lung cancer

lung adenocarcinoma

immunohistochemistry

TCGA database

immune-related genes

tumor-infiltrating immune cells

therapeutic interventions

Fujian Medical University