2024 World Conference on Lung Cancer (WCLC) - Posters-P1.06B.15 The Role and Clinical Significance of the MICOS Family in Lung Adenocarcinoma: A Focus on MIC19

P1.06B.15 The Role and Clinical Significance of the MICOS Family in Lung Adenocarcinoma: A Focus on MIC19

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This study investigates the role of the MICOS family of genes, particularly MIC19, in lung adenocarcinoma by analyzing data from The Cancer Genome Atlas and other databases, and through experimental manipulation using siRNA. The MICOS family is crucial for maintaining mitochondrial structure and function, which is often altered in cancers, including lung adenocarcinoma. This research aims to understand the emergence and progression of lung adenocarcinoma and its clinical implications.<br /><br />Bioinformatics analyses indicated that genes in the MICOS family were aberrantly expressed in lung adenocarcinoma tissues, with MIC19 being closely linked to malignant characteristics and having the strongest connection to clinical features of severity. Furthermore, MIC19 expression corresponded significantly with the abundance of immune cell infiltration within these cancer tissues, suggesting its potential as a prognostic marker.<br /><br />Experimental results showed that reducing MIC19 expression in lung adenocarcinoma cells led to decreased cell proliferation and migration, reinforcing its role in promoting tumor aggressiveness. These findings propose that MIC19 could serve as a novel, independent prognostic biomarker, and a potential therapeutic target for lung adenocarcinoma, offering new insights and potential approaches for its treatment and prognosis assessment.<br /><br />The study marks the first comprehensive examination of the MICOS family's involvement in lung adenocarcinoma, highlighting the critical role of MIC19, providing a new direction for clinical strategies in managing this cancer type.

Asset Subtitle

Xuanguang Li

Meta Tag

Speaker Xuanguang Li

Topic Pathology & Biomarkers

Keywords

MICOS family

MIC19

lung adenocarcinoma

The Cancer Genome Atlas

siRNA

mitochondrial structure

immune cell infiltration

prognostic biomarker

tumor aggressiveness

therapeutic target