2024 World Conference on Lung Cancer (WCLC) - Posters-P1.06C.06 The Prognostic Impacts of Three Invasive Patterns in Pulmonary Peripheral Squamous Cell Carcinoma

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This study, conducted by Hideto Iguchi and colleagues, investigates the relationship between invasive patterns in pulmonary peripheral squamous cell carcinoma (SqCC) and patient prognosis. SqCC represents about 20% of non-small cell lung cancers, predominantly found in male smokers and usually originating centrally within the lung. Recently, however, peripheral lung disease has been on the rise, with limited resections proving clinically useful for small peripheral lung cancers.<br /><br />The research focuses on determining the histopathological growth and invasive patterns in small peripheral SqCCs and correlating these patterns with prognosis. In the context of adenocarcinoma, different invasive patterns have been linked to varying survival rates; the study aims to explore similar correlations in SqCC.<br /><br />154 patients who underwent surgery for SqCC at Wakayama Medical University between January 2016 and March 2022 were considered. After exclusions, 70 cases of peripheral-located tumors were examined. The study employed immunohistochemical staining to evaluate tumor invasion and alveolar structures.<br /><br />The invasive patterns identified include Intra-alveolar filling (IAF), Lepidic (LP) growth, and Destructive (DES) patterns, with variations such as IAF/I-AR (intra-alveolar with alveolar remain), LP/P-AR (lepidic/peri-alveolar with alveolar remain), and DES/N-AR (destructive with no alveolar remain). Findings indicated a correlation between invasive patterns at the tumor margins and those within the tumor.<br /><br />The presence of intra-tumorous remnants of alveolar structures, specifically I-AR and P-AR patterns, is associated with a good prognosis. This suggests that a quantitative evaluation of residual alveolar structures could serve as a prognostic indicator for patients with small-sized peripheral SqCCs, which are expected to increase in frequency. This study underscores the potential role of histopathological patterns in guiding prognosis and treatment decisions in lung cancer.

Asset Subtitle

Hideto Iguchi

Meta Tag

Speaker Hideto Iguchi

Topic Pathology & Biomarkers

Keywords

pulmonary peripheral squamous cell carcinoma

patient prognosis

non-small cell lung cancer

invasive patterns

histopathological growth

immunohistochemical staining

alveolar structures

prognostic indicator

Hideto Iguchi

lung cancer treatment