2024 World Conference on Lung Cancer (WCLC) - Posters-P1.08D.04 The Clinical Outcomes of Contralateral Esophagus Sparing IMRT in Concurrent Chemoradiotherapy for Stage III Lung Cancer

P1.08D.04 The Clinical Outcomes of Contralateral Esophagus Sparing IMRT in Concurrent Chemoradiotherapy for Stage III Lung Cancer

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The study examines the use of contralateral esophagus sparing intensity modulated radiation therapy (CES-IMRT) in the treatment of Stage III non-small cell lung cancer (NSCLC) patients undergoing concurrent chemoradiotherapy (dCCRT). Radiation esophagitis often occurs with high-dose thoracic radiation therapies, impacting patient comfort and quality of life.<br /><br />The researchers aimed to evaluate the impact of CES-IMRT on both the severity of acute esophagitis and the risk of intrathoracic tumor control. Between January 2021 and May 2023, 183 NSCLC patients were treated with dCCRT. Out of these, 159 patients necessitated CES due to the proximity of the esophagus to the internal target volume (ITV). CES-IMRT was applied to 41 patients, while the remaining 118 did not receive this technique.<br /><br />Results demonstrated that CES-IMRT significantly reduced both the frequency and severity of acute radiation esophagitis without compromising oncological outcomes, as indicated by measures like pain-killer usage and Analgesic Quantification Algorithm (AQA) scores. Furthermore, no differences were observed between CES-applied and -unapplied groups in progression-free, intrathoracic failure-free, and overall survival. Notably, only CES-unapplied patients experienced a marginal intrathoracic failure.<br /><br />The study concludes that CES-IMRT application leads to reduced esophagitis without increasing marginal failure risks, suggesting potential benefits in clinical practice. However, the authors advocate for further randomized studies to confirm these findings and optimize treatment protocols.

Asset Subtitle

Yong Chan Ahn

Meta Tag

Speaker Yong Chan Ahn

Topic Local-Regional NSCLC

Keywords

CES-IMRT

Stage III NSCLC

radiation esophagitis

dCCRT

thoracic radiation

intrathoracic tumor control

Analgesic Quantification Algorithm

oncological outcomes

marginal intrathoracic failure

randomized studies