2024 World Conference on Lung Cancer (WCLC) - Posters-P1.13B.02 Radiation Necrosis in Small Cell Lung Cancer Patients

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This study conducted at the Davidoff Cancer Center in Israel analyzed 96 small cell lung cancer (SCLC) patients, focusing on those with brain metastasis between 2019 and 2022. Of these patients, 47 (49%) had brain metastasis, and 34 (72.3%) received radiation therapy. Specifically, 22 patients (64.7%) underwent whole brain radiation therapy (WBRT), while the remaining 12 (35.3%) received stereotactic radiosurgery (SRS). In addition, 20 out of the 34 patients receiving radiation also underwent immunotherapy either simultaneously or sequentially.<br /><br />SRS, a more targeted form of radiation, was shown to be a safe treatment option, even when combined with immunotherapy, as no patients were diagnosed with radiation necrosis, a potential side effect. The study further reveals survival data: patients receiving SRS lived a median of 100 days, whereas those undergoing WBRT had a median survival of 140 days. Of the patients treated with SRS, 66.6% survived over three months, with 33.3% surviving beyond six months. In the WBRT group, 72.7% survived past three months, and 36.3% lived longer than six months.<br /><br />The study highlights that advanced radiation techniques like SRS, combined with immunotherapy, can improve the quality of life and potentially extend survival without increasing the risk of radiation necrosis. However, it reports a slightly shorter median survival rate for patients treated with SRS compared to those treated with WBRT. The results emphasize the need for further research on the occurrence of radiation necrosis in SCLC patients who receive combined therapies.

Asset Subtitle

Oded Icht

Meta Tag

Speaker Oded Icht

Topic SCLC & Neuroendocrine Tumors

Keywords

Davidoff Cancer Center

small cell lung cancer

brain metastasis

radiation therapy

whole brain radiation therapy

stereotactic radiosurgery

immunotherapy

radiation necrosis

survival data

advanced radiation techniques