2024 World Conference on Lung Cancer (WCLC) - Posters-P2.04A.01 FIRSTLUNG (L301): Cluster Randomized Trial Evaluating the Clinical Utility of DELFI's Blood-Based Lung Cancer Screening Test

P2.04A.01 FIRSTLUNG (L301): Cluster Randomized Trial Evaluating the Clinical Utility of DELFI's Blood-Based Lung Cancer Screening Test

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The study outlined in the document focuses on increasing lung cancer screening among eligible individuals in primary care practices. It operates under specific inclusion and exclusion criteria. Inclusion criteria mandate that the practice offers primary care services and includes at least 50 patients who meet lung cancer screening eligibility according to the 2021 USPSTF guidelines: individuals aged 50-80 with a significant smoking history. Practices must also have electronic medical record (EMR) data capabilities and physical and insurance access to low-dose computed tomography (LDCT).<br /><br />The study excludes practices participating in other DELFI lung studies or any cancer screening biomarker studies returning results. The primary outcome measures focus on the proportion of eligible individuals receiving a CT scan for lung cancer screening.<br /><br />The study is carried out across nine states, including Arizona, Colorado, and Texas, with a targeted completion by December 2025. It started in October 2023 and has enrolled about 13,000 eligible participants so far. Practices are randomized into two arms: Control (Arm A) and Intervention (Arm B). Within Arm A, practices are further divided into groups A1 (usual care) and A2 (usual care plus CME on lung screening). Arm B receives additional education on and access to pWGFrag-Lung along with CME.<br /><br />The study measures the effectiveness of these interventions over 15 months, comparing the screening uptake between the control and intervention arms. These methods were presented at the IASLC World Conference on Lung Cancer in September 2024. For reuse or distribution of the presentation content, contact DELFI Diagnostics.

Asset Subtitle

Lindsey Cotton

Meta Tag

Speaker Lindsey Cotton

Topic Screening & Early Detection

Keywords

lung cancer screening

primary care

USPSTF guidelines

low-dose computed tomography

electronic medical records

randomized study

intervention arms

IASLC World Conference

DELFI Diagnostics

smoking history