2024 World Conference on Lung Cancer (WCLC) - Posters-P2.04A.04 The Lung Health Check Pilot: Ireland's Flagship Lung Cancer Screening Trial

Pdf Summary

The document outlines the Lung Health Check Pilot, a flagship lung cancer screening trial in Ireland, aimed at establishing a community-based lung cancer screening (LCS) program for high-risk individuals aged 55-74. Conducted by a consortium comprising RCSI University of Health Sciences, Beaumont RCSI Cancer Centre, Trinity St. James’ Cancer Institute, and the Sidney Kimmel Comprehensive Cancer Centre at Johns Hopkins University, the study builds on successful UK pilots and international best practices derived from the NLST and NELSON studies.<br /><br />The trial hypothesizes that LCS, involving invitations through primary care and community engagement, will be well-received among local populations, leading to a significant uptake that could justify a national program. Funded by the Irish Cancer Society and the EU’s Solace Consortium, the primary endpoint focuses on the proportion of eligible high-risk participants engaging in the lung health checks.<br /><br />Secondary endpoints include clinical management outcomes such as lung cancer and COPD detection through baseline spirometry and respiratory health questionnaires, nodule detection rates, and smoking behaviour changes post-intervention. The trial will also identify genomic, proteomic, and immunological markers predictive of lung cancer from blood and breath samples. Additionally, it will evaluate the economic viability of the program, examining cost-effectiveness, intervention costs, and long-term economic impacts.<br /><br />The trial involves inviting approximately 29,000 individuals to ensure sufficient numbers of ever-smokers are assessed. The Lung Health Check includes respiratory assessment, spirometry, smoking cessation interventions, low-dose chest CT, and optional biospecimen collection. Incidental findings and nodule detections will be surveilled, with follow-ups conducted at three months and one year.<br /><br />Overall, the study seeks to implement a sustainable community-based LCS program by incorporating innovative approaches and leveraging existing predictive models to enhance lung cancer detection and management in Ireland.

Asset Subtitle

David O Reilly

Meta Tag

Speaker David O Reilly

Topic Screening & Early Detection

Keywords

Lung Health Check Pilot

lung cancer screening

Ireland

high-risk individuals

community-based program

RCSI University

genomic markers

economic viability

smoking cessation

low-dose chest CT