2024 World Conference on Lung Cancer (WCLC) - Posters-P2.07B.01 Single Versus Multiple Segmentectomies: A Comparison of Short- And Long-Term Outcomes

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The study compares the short- and long-term outcomes of single versus multiple lung segmentectomies in patients with early-stage non-small cell lung cancer (NSCLC). Conducted by a team led by Dr. Fatemehsadat Pezeshkian at Brigham and Women’s Hospital, the research examines anatomic segmentectomies performed between August 1, 2005, and May 31, 2023, involving 693 patients—354 underwent single segmentectomy, and 339 had multiple segmentectomies.<br /><br />The primary aim was to determine whether multiple segmentectomies offer better locoregional control and outcomes compared to single segmentectomies. The study reports the 5-year overall survival rates as 72.8% for single segmentectomy and 75.9% for multiple segmentectomies, with no statistically significant difference between them (p=0.28). However, the 5-year cumulative incidence of locoregional recurrence was significantly higher in single segmentectomy (17%) compared to multiple segmentectomies (10%) (p=0.03).<br /><br />The researchers used multivariable Cox regression analysis to adjust for high-risk pathologic features and tumor size, finding that multiple segmentectomy remained associated with a lower risk of locoregional recurrence (CSHR 0.39, 95% CI 0.22-0.70). In subgroup analyses, even after adjusting for margin length and other features, this association persisted, though the effect size was reduced (CSHR 0.55, 95% CI 0.31-0.98).<br /><br />The study suggests that while multiple segmentectomy may provide superior locoregional control by ensuring adequate margins, this advantage does not significantly impact overall survival. Further research is necessary to refine the selection criteria for single and multiple segmentectomies to optimize surgical decision-making for patients with early-stage NSCLC.

Asset Subtitle

FATEMEHSADAT PEZESHKIAN

Meta Tag

Speaker FATEMEHSADAT PEZESHKIAN

Topic Early-Stage NSCLC

Keywords

lung segmentectomy

non-small cell lung cancer

NSCLC

early-stage cancer

locoregional control

overall survival

Cox regression analysis

Brigham and Women’s Hospital

surgical decision-making

tumor recurrence