2024 World Conference on Lung Cancer (WCLC) - Posters-P2.07B.05 Prospective Comparative Study of Postoperative Respiratory Function after Lobectomy Versus Segmentectomy

Pdf Summary

This study evaluates the postoperative respiratory function following lobectomy and segmentectomy in patients with lung cancer. It includes 510 patients operated on between January 2021 and March 2023, with 228 undergoing lobectomy and 282 undergoing segmentectomy. The study excludes patients with metachronous lung resections, scheduling respiratory function tests preoperatively, and again at 6 months and 1 year postoperatively.<br /><br />Key findings indicate that segmentectomy preserves postoperative respiratory function better than lobectomy. Significant differences in the reduction rates of forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) were observed in surgeries of the right and left upper lobes, but not significantly in the lower lobes, except for the left S8 segmentectomy.<br /><br />Data analysis shows variations across different lobes or segments. Right upper segmentectomy demonstrated a tendency to better preserve respiratory function, aligning with previous studies. Factors contributing to the differences were not definitively established, though speculations include the "shift" of the remaining lung within the thoracic cavity, potentially influencing recovery. This warrants further investigation into lung behavior post-surgery.<br /><br />Patient demographics showed a median age of 70 years, comprising slightly more males than females, and highlighted differences in clinical and pathological stages between the two surgical groups. The study suggests that the degree of postoperative respiratory function preservation, which varies by the surgical site, could be a crucial factor when selecting candidates for segmentectomy.<br /><br />Overall, this non-randomized prospective study underscores the comparative advantages of segmentectomy over lobectomy regarding postoperative respiratory outcomes, although further research is needed to fully understand the underlying mechanics of lung recovery and the variability among different surgical sites.

Asset Subtitle

Chihiro Takemura

Meta Tag

Speaker Chihiro Takemura

Topic Early-Stage NSCLC

Keywords

postoperative respiratory function

lobectomy

segmentectomy

lung cancer

forced vital capacity

forced expiratory volume

right upper segmentectomy

lung recovery

thoracic cavity

patient demographics