2024 World Conference on Lung Cancer (WCLC) - Posters-P2.07B.07 Multi-Institutional Retrospective Analysis of Segmentectomy Versus Lobectomy for Non-Small Cell Lung Cancer Larger Than 3 cm in Diameter

P2.07B.07 Multi-Institutional Retrospective Analysis of Segmentectomy Versus Lobectomy for Non-Small Cell Lung Cancer Larger Than 3 cm in Diameter

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The study conducts a multi-institutional retrospective analysis comparing segmentectomy and lobectomy for non-small cell lung cancer (NSCLC) larger than 3 cm in diameter. Conducted across three Japanese medical institutions between 2010 and 2022, this research investigates the viability of segmentectomy as an alternative treatment for NSCLC above 3 cm in size, focusing on the importance of choosing the right candidates for such procedures.<br /><br />The inclusion criteria for the study were patients diagnosed with NSCLC with tumor sizes larger than 3 cm, identified to be radiologically staged as cN0 through PET/CT and/or EBUS-TBNA, and who underwent curative anatomical resections. Out of 1208 cases analyzed, the study utilized Propensity Score Matching (PSM) to ensure a balanced comparison between the segmentectomy and lobectomy groups, with a median follow-up period of 42.9 months.<br /><br />Results indicated that segmentectomy is more frequently performed in cases involving the left upper lobe. An important factor related to cancer recurrence was identified as the solid tumor size rather than the whole tumor size. Special attention is advised for tumors with a consolidation-to-tumor ratio (CTR) of 1. Importantly, the study concludes that, when patients are appropriately selected, segmentectomy shows a comparable prognosis to lobectomy. This suggests that segmentectomy with correct candidate selection could diversify treatment strategies for NSCLC.<br /><br />The findings advocate for segmentectomy as a legitimate surgical option for larger NSCLC lesions, highlighting its potential to achieve similar outcomes to lobectomy. This approach could broaden treatment possibilities, offering a less extensive surgical alternative without compromising patient prognosis.

Asset Subtitle

Yujin Kudo

Meta Tag

Speaker Yujin Kudo

Topic Early-Stage NSCLC

Keywords

non-small cell lung cancer

segmentectomy

lobectomy

NSCLC

retrospective analysis

Propensity Score Matching

tumor size

cancer recurrence

consolidation-to-tumor ratio

surgical treatment