2024 World Conference on Lung Cancer (WCLC) - Posters-P2.07B.08 Outcome Comparison Between Left Upper Lung Lobectomy and Split Lobe Segmentectomy for Clinical Stage I Lung Cancer

P2.07B.08 Outcome Comparison Between Left Upper Lung Lobectomy and Split Lobe Segmentectomy for Clinical Stage I Lung Cancer

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The study by Tzu-Ning Kao at the National Taiwan University Hospital compares two surgical procedures, left upper lung lobectomy and split lobe segmentectomy (trisegmentectomy/lingulectomy), for treating clinical stage I non-small cell lung cancer (NSCLC). The primary focus is on determining whether a less invasive surgery (split-lobe segmentectomy) can achieve outcomes comparable to the more extensive lobectomy while preserving lung function and minimizing perioperative complications.<br /><br />The paper involved a review of patient cases from 2011 to 2021, focusing on those who had tumors between 2-4 cm. The study utilized propensity score matching to control for prognostic factors and present a fair comparison. The main findings emphasized that the split lobe segmentectomy offered equivalent oncological outcomes to lobectomy, such as overall survival and progression-free survival, without increasing the risk of cancer progression or mortality.<br /><br />Further, the segmentectomy showed a benefit of shorter operative times and reduced ICU and hospital stay durations, highlighting improved perioperative outcomes. This procedure also resulted in better preservation of lung function, as determined by lesser decline in pulmonary function compared to lobectomy.<br /><br />The study suggests that the split lobe segmentectomy is a viable alternative to lobectomy, particularly for those patients unable to undergo the more invasive traditional surgery. However, it notes limitations such as the retrospective nature of the study and recommends future multicenter prospective trials for more robust conclusions. These findings contribute to ongoing research advocating for lung-sparing surgical options in managing early-stage lung cancer.

Asset Subtitle

Tzu-Ning Kao

Meta Tag

Speaker Tzu-Ning Kao

Topic Early-Stage NSCLC

Keywords

lung cancer

lobectomy

segmentectomy

NSCLC

oncological outcomes

lung function

perioperative complications

propensity score matching

surgical procedures

retrospective study