2024 World Conference on Lung Cancer (WCLC) - Posters-P2.11A.16 Categorizing Steroid-Response Types in Checkpoint Inhibitor-Related Pneumonitis

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The study focuses on categorizing response types to glucocorticoids (GCs) in patients suffering from checkpoint inhibitor-related pneumonitis (CIP). Researchers from the First Affiliated Hospital of Guangzhou Medical University retrospectively analyzed 98 CIP patients and proposed a classification system dividing them into four distinct glucocorticoid response types: sensitive, refractory, dependent, and resistant.<br /><br />Glucocorticoids, as a primary treatment, show variable effectiveness among patients. Classifying these response types assists clinicians in tailoring subsequent treatment strategies effectively. The study found that 18.4% of the patients exhibited a steroid-refractory response upon the first occurrence of CIP. Comparatively, steroid-sensitive patients frequently reached disease stabilization, even though some transitioned into a steroid-dependent category with relapses.<br /><br />Data analysis revealed that steroid-refractory and -resistant types presented with higher severity of CIP and poorer Performance Status (PS) scores than their sensitive and dependent counterparts. Additionally, steroid-refractory patients showed significantly lower CD4 T-cell counts, and steroid-resistant cases had heightened IL-8 cytokine levels. These patients generally experienced higher rates of other immune-related adverse events (irAEs) and demonstrated shorter overall survival (OS) times.<br /><br />The study underscores the importance of identifying specific biological markers such as IL-8 levels and CD4 T-cell counts to predict the likelihood of developing steroid-refractory or -resistant CIP. These insights allow for a more nuanced approach in managing CIP, potentially improving patient outcomes through more personalized treatment regimens. The authors conclude that certain clinical characteristics and biomarker profiles can help anticipate steroid non-responsiveness, aiding in better therapeutic decision-making in CIP cases.

Asset Subtitle

Yilin Yang

Meta Tag

Speaker Yilin Yang

Topic Metastatic NSCLC – Immunotherapy

Keywords

glucocorticoids

checkpoint inhibitor-related pneumonitis

CIP

glucocorticoid response types

steroid-refractory

steroid-sensitive

steroid-dependent

steroid-resistant

biomarkers

personalized treatment