2024 World Conference on Lung Cancer (WCLC) - Posters-P2.14B.02 Application of Chemokine Receptor 4 Targeted 68Ga Pentixafor in Evaluation of Thymic Epithelial Tumors (TETs): A Prospective Study

P2.14B.02 Application of Chemokine Receptor 4 Targeted 68Ga Pentixafor in Evaluation of Thymic Epithelial Tumors (TETs): A Prospective Study

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This prospective study explores the use of 68Ga-Pentixafor, a radiotracer targeting the C-X-C chemokine receptor 4 (CXCR4), for the non-invasive diagnosis of thymic epithelial tumors (TETs). CXCR4 is a receptor overexpressed on several tumor surfaces and is linked with poor prognosis in TETs, especially those associated with myasthenia gravis. The study involves PET/CT scans and evaluates CXCR4 expression using RNA sequencing techniques.<br /><br />The study enrolled 22 patients with suspected TETs, using 68Ga-Pentixafor PET/CT to identify and evaluate tumor lesions before comparing these results with surgical pathology findings. The PET/CT effectively identified TETs in all 11 confirmed cases, showing high uptake values (mean SUVmax of 13.9) compared to non-TETs (mean SUVmax of 2.2), indicating the potential efficacy of 68Ga-Pentixafor in distinguishing TETs.<br /><br />Bulk RNA-seq analysis confirmed increased CXCR4 gene expression in TETs compared to normal thymic tissue, with data showing significant gene upregulation. Single nuclei RNA sequencing (snRNA-seq) further detailed CXCR4 distribution, primarily within TET immune cells, corroborated by immunohistochemical staining of tumor stroma.<br /><br />This study suggests 68Ga-Pentixafor's promising role in TET evaluation, providing crucial insights into CXCR4's involvement in tumor pathology. This research is part of ongoing clinical trials registered under ClinicalTrials.gov identifier NCT06086327. For further details, contact corresponding authors Xuehan Gao, MD, and Yeye Chen, MD, at Peking Union Medical College Hospital, Beijing, China.

Asset Subtitle

Xuehan Gao

Meta Tag

Speaker Xuehan Gao

Topic Mesothelioma, Thymoma & Other Thoracic Tumors

Keywords

68Ga-Pentixafor

CXCR4

thymic epithelial tumors

TETs

PET/CT

RNA sequencing

myasthenia gravis

tumor diagnosis

SUVmax

clinical trials