2024 World Conference on Lung Cancer (WCLC) - Posters-P3.01E.02 Association Between Composite Dietary Antioxidant Index and Lung Cancer Risk in Former Smokers: A Large Prospective Cohort Study in UK Biobank

P3.01E.02 Association Between Composite Dietary Antioxidant Index and Lung Cancer Risk in Former Smokers: A Large Prospective Cohort Study in UK Biobank

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This study investigates the relationship between the Composite Dietary Antioxidant Index (CDAI) and lung cancer risk using data from the UK Biobank. The CDAI is derived from the dietary intake of magnesium, selenium, zinc, and vitamins A, C, and E. Conducted over 11.8 years, this prospective cohort study aimed to clarify the inconsistent findings of previous research on antioxidant intake and lung cancer prevention.<br /><br />Key findings indicate that higher CDAI levels are linked to a lower risk of lung cancer. The multivariable-adjusted analysis suggests a significant inverse association between CDAI and lung cancer risk, with a hazard ratio (HR) of 0.97 (95% CI: 0.95-0.99, P = 0.003). An interaction between CDAI and smoking status was notable, highlighting that former smokers in the highest CDAI quartile had a reduced HR of 2.68 compared to those in the lowest quartile, who had an HR of 4.32. This suggests that dietary antioxidants may mitigate the adverse effects of smoking. Additionally, a significant non-linear association was observed among former smokers, where lung cancer risk decreased notably when CDAI exceeded -3.9 (P = 0.0165).<br /><br />The study underscores the importance of dietary antioxidants in reducing lung cancer risk, particularly for smokers and former smokers. Future research should focus on understanding the biological mechanisms by which antioxidants provide protective effects and developing targeted dietary interventions for former smokers.<br /><br />The research was conducted using resources from the UK Biobank, with the authors acknowledging the contributions of participants and researchers in this prospective cohort study. This work emphasizes dietary antioxidants as a potential means of reducing lung cancer risk and highlights the need for continued investigation into their protective effects.

Asset Subtitle

Yi Feng

Meta Tag

Speaker Yi Feng

Topic Risk Factors, Risk Reduction & Tobacco Control

Keywords

Composite Dietary Antioxidant Index

CDAI

lung cancer risk

UK Biobank

dietary antioxidants

smoking status

hazard ratio

prospective cohort study

antioxidant intake

former smokers