2024 World Conference on Lung Cancer (WCLC) - Posters-P3.01F.02 Retrospective Characterization of Patients with Primary Lung Cancer Related to World Trade Center Disaster Exposure

P3.01F.02 Retrospective Characterization of Patients with Primary Lung Cancer Related to World Trade Center Disaster Exposure

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The study focuses on a cohort of 298 lung cancer patients with documented World Trade Center (WTC) exposure, treated at NYU Langone Health between 2005 and 2023. The research evaluates the impact of the WTC disaster exposure on lung cancer diagnosis and progression, aiming to provide insights for healthcare providers. <br /><br />Key findings indicate a higher rate of early-stage diagnosis (Stage I and II) among these patients compared to the general lung cancer population in the United States, where diagnosis typically occurs at later stages (III-IV). Specifically, 50% of patients were diagnosed at Stage I, and 7.2% at Stage II. This earlier diagnosis might be attributed to targeted screening efforts through the WTC Medical Monitoring and Treatment Program, as these patients would generally not meet the national screening criteria based on their pack year histories.<br /><br />The study highlights unique aspects of this patient population; for instance, among patients with a smoking history, 52 had less than 20 pack year histories, while 27% had no smoking history at all. Notably, non-smokers had the highest proportion of Stage IV diagnoses. Patients diagnosed at higher stages (III-IV) exhibited worse outcomes, including disease progression and death, particularly in those identified as having significant exposure types, such as resident or commuter.<br /><br />The study underscores the need for focused research on WTC-exposed individuals to better understand potential genetic and clinical differences in lung cancer pathophysiology compared to other exposure histories. Through such comprehensive analysis, the goal is to enhance early detection and treatment outcomes for those impacted by the WTC disaster. The study involves methods like retrospective chart review, statistical tests, and clustering analysis to explore various demographic and clinical features of the cohort.

Asset Subtitle

Julia Lo Cascio

Meta Tag

Speaker Julia Lo Cascio

Topic Risk Factors, Risk Reduction & Tobacco Control

Keywords

lung cancer

World Trade Center

early-stage diagnosis

NYU Langone Health

WTC Medical Monitoring

smoking history

genetic differences

retrospective chart review

clustering analysis

exposure types