2024 World Conference on Lung Cancer (WCLC) - Posters-P3.02F.01 CD47 Promotes Migration and Metastasis in Non-Small Cell Lung Cancer

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CD47, a widely overexpressed cell surface protein in non-small cell lung cancer (NSCLC), functions as a "don't eat me" signal, inhibiting cancer cell phagocytosis by macrophages and promoting tumor immune evasion. High CD47 levels correlate with poorer survival rates, advanced tumor stages, and increased metastasis in NSCLC patients, suggesting it plays a crucial role in cancer progression. Although CD47's involvement in cancer migration and metastasis is documented, the specific mechanisms controlling these processes in NSCLC remain poorly understood.<br /><br />Recent research aims to understand better the role of CD47 in NSCLC metastasis, which could justify using CD47-targeted therapies to combat both metastatic spread and immune escape in these cancers. This study focuses on how CD47 influences signal transduction pathways that facilitate cell migration, invasion, and metastasis. Through creating lung cancer models with CD47 loss-of-function (LOF), researchers observed that CD47 LOF impairs lung cancer cell migration and metastasis in both in vitro and in vivo scenarios, potentially through pathways involving FAK and AKT.<br /><br />Despite reduced fitness in vivo, CD47-deficient lung cancer cells do not exhibit impaired fitness in vitro. Knockout models demonstrate prolonged survival compared to wild-type controls, reinforcing CD47's role in tumor progression. Future research involves validating these migration and metastasis phenotypes across additional NSCLC models without CD47 and further elucidating the metastasis signaling pathways regulated by CD47.<br /><br />By targeting CD47, therapies might not only disrupt immune evasion but also hinder metastatic dissemination, providing a dual mechanism to impair NSCLC progression. This research underscores the therapeutic potential of CD47-targeted interventions in managing NSCLC's aggressive and metastatic behaviors.

Asset Subtitle

Kelsie Thu

Meta Tag

Speaker Kelsie Thu

Topic Tumor Biology – Preclinical Biology

Keywords

CD47

NSCLC

immune evasion

metastasis

cancer progression

signal transduction

FAK

AKT

targeted therapy

tumor stages