2024 World Conference on Lung Cancer (WCLC) - Posters-P3.03H.02 PMS2 Amplification Contributes Brain Metastasis from Lung Cancer

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The study by Jianing Chen and Chunxia Su explores the mechanisms behind brain metastasis in lung adenocarcinoma patients, focusing on the gene PMS2. Brain metastasis from lung adenocarcinoma significantly increases patient mortality, highlighting the need for a deeper understanding of its biological drivers. The researchers gathered cerebrospinal fluid and plasma samples from 114 patients with lung adenocarcinoma and brain metastasis for a comprehensive gene sequencing analysis.<br /><br />Results identified PMS2 amplification as a potential driver of brain metastasis. The study used various assays to validate the hypothesis: wound healing and migration assays demonstrated the enhanced migratory and invasive capabilities of PMS2-amplified lung cancer cells, specifically in PC-9 and LLC cell lines. Further in vivo imaging supported these findings by showing enhanced colonization of mouse brains by these cancer cells.<br /><br />RNA sequencing indicated significant differences in gene expression between PMS2-amplified and wild-type lung cancer cells, with pathways involved in thiamine, butanoate, and glutathione metabolism being notably enriched in PMS2-amplified cells. These metabolic pathways potentially contribute to the enhanced metastatic ability observed.<br /><br />The conclusion drawn from the study is that PMS2 amplification increases the metastatic potential of lung cancer cells, facilitating their ability to form brain colonies through specific metabolism pathways. The insight gained from this research underscores the role of metabolic changes in cancer metastasis and suggests that targeting these pathways could be a productive avenue for future therapies aimed at preventing or treating brain metastases in lung adenocarcinoma patients.

Asset Subtitle

Jianing Chen

Meta Tag

Speaker Jianing Chen

Topic Tumor Biology – Translational Biology

Keywords

brain metastasis

lung adenocarcinoma

PMS2 gene

patient mortality

gene sequencing

cancer cell migration

metabolic pathways

RNA sequencing

therapeutic targets

cancer metastasis