2024 World Conference on Lung Cancer (WCLC) - Posters-P3.03I.09 Augmenting Post-Surgical Tumor Immune Response and Recurrence Prevention via Nanoparticle-Assisted Targeted Drug Delivery

P3.03I.09 Augmenting Post-Surgical Tumor Immune Response and Recurrence Prevention via Nanoparticle-Assisted Targeted Drug Delivery

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The study outlined in the document addresses the challenge of post-surgical tumor recurrence in lung cancer patients by leveraging a Nanoparticle-Assisted Targeted Drug Delivery System (NDDS). This innovative method aims to enhance the immune response using the ferroptosis mechanism, which induces immunogenic cell death (ICD) and activates the STING pathway. The targeted drug delivery system, named FP/Vad@CC-aT2, demonstrates significant antitumor effects and immune remodeling, offering a promising strategy for personalized treatment.<br /><br />A mouse model simulating postoperative tumor recurrence was established to evaluate the system's efficacy. The FP/Vad@CC-aT2 treatment notably inhibited tumor growth without causing significant changes in body weight, indicating its relative safety. Immunohistochemical analyses showed an increased expression of indicators of immunogenic cell death, while flow cytometry revealed enhanced infiltration of M1-type macrophages and CD8 T cells, alongside a reduction in regulatory T cells, suggesting a favorable tumor microenvironment shift.<br /><br />Future research directions are proposed, focusing on optimizing the system for clinical trials and enhancing its therapeutic potential by combining it with other treatment modalities. This approach could pave the way for more effective and personalized cancer treatments, underlining FP/Vad@CC-aT2’s potential in preventing post-surgical relapse.<br /><br />The research was supported by the Natural Science Foundation of Guangdong and developed through collaborations between multiple medical and scientific institutions in Guangzhou, China. The findings contribute to advancing targeted cancer therapies by not only inhibiting tumor growth but also enhancing the immune system’s natural defenses.

Asset Subtitle

Weijie Zhan

Meta Tag

Speaker Weijie Zhan

Topic Tumor Biology – Translational Biology

Keywords

Nanoparticle-Assisted Targeted Drug Delivery System

lung cancer

ferroptosis mechanism

immunogenic cell death

STING pathway

FP/Vad@CC-aT2

immune remodeling

post-surgical tumor recurrence

personalized treatment

Natural Science Foundation of Guangdong