2024 World Conference on Lung Cancer (WCLC) - Posters-P3.06F.07 Effect of Neoadjuvant Chemotherapy on the Spatial Landscape of Regulatory T Cells in Non-Small Cell Lung Cancer Patients

P3.06F.07 Effect of Neoadjuvant Chemotherapy on the Spatial Landscape of Regulatory T Cells in Non-Small Cell Lung Cancer Patients

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The document discusses a study examining the effects of Neoadjuvant Chemotherapy (NAC) on the regulatory T cells (Tregs) within the tumor microenvironment in patients with non-small cell lung cancer (NSCLC). Conducted by researchers at Shandong University Cancer Center and Shandong Cancer Hospital, the study aims to understand how NAC influences the spatial architecture and density of Tregs, with implications for patient prognosis and treatment outcomes.<br /><br />Key findings indicate that after NAC, there was an increase in cell density (Den), infiltration score (InS), and Treg-cell proximity score (TrPS) for Tregs, as well as the TrPS for CD8 T cells. This suggests that NAC can alter the spatial dynamics and intratumoral infiltration of Tregs, potentially affecting the therapeutic response and clinical outcomes for NSCLC patients. <br /><br />The study also observed negative associations between cancer-associated fibroblasts (CAFs), cancer-associated macrophages (CMVs), and the TrPS scores for CD8 and CD4 T cells, indicating complex interplays in the tumor microenvironment that can influence disease progression and treatment effectiveness.<br /><br />The researchers conclude that a personalized treatment approach, informed by the modified spatial architecture of Tregs post-NAC, could enhance the efficacy of combination therapies and improve patient outcomes. Future research directions include refining personalized treatment strategies to fully utilize the insights gained from the altered spatial landscapes of Tregs following chemotherapy.<br /><br />The document also references other studies exploring the relationship between tumor-infiltrating T cells and clinical outcomes, providing a context for understanding how spatial interactions within tumors correlate with patient survival.

Asset Subtitle

Ligang Xing

Meta Tag

Speaker Ligang Xing

Topic Pathology & Biomarkers

Keywords

Neoadjuvant Chemotherapy

regulatory T cells

tumor microenvironment

non-small cell lung cancer

Shandong University Cancer Center

cell density

infiltration score

Treg-cell proximity score

cancer-associated fibroblasts

personalized treatment