2024 World Conference on Lung Cancer (WCLC) - Posters-P3.13C.08 Optimal Treatment Strategies for Older Adults with Clinical Stage IA Small Cell Lung Cancer

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The study titled "Optimal Treatment Strategies for Older Adults with Clinical Stage IA Small Cell Lung Cancer" explores treatment patterns and survival outcomes for patients aged 80-89 diagnosed with stage IA small cell lung cancer (SCLC) using data from the National Cancer Database from 2004 to 2021. The research aimed to evaluate the efficacy of different treatment modalities in this elderly cohort.<br /><br />The study found a significant shift in treatment patterns over the years, particularly an increased adoption of Stereotactic Body Radiation Therapy (SBRT) by 2021, making it the most prevalent treatment modality for this age group over the last two decades. The study compared the overall survival rates associated with various treatments, including surgery, SBRT, chemotherapy alone, non-SBRT radiation, and no treatment.<br /><br />Multivariable analysis indicated that SBRT and surgery provided comparable survival benefits, both outperforming other treatment options. Specifically, chemotherapy alone and non-SBRT radiation were linked to significantly worse survival outcomes compared to SBRT and surgery. Notably, the proportion of patients receiving chemotherapy alone or no treatment decreased over the study period.<br /><br />In terms of five-year survival rates, surgery (33.6%) and SBRT (21.0%) showed higher efficacy compared to chemotherapy (19.7%), non-SBRT radiation (5.8%), and no treatment (8.4%). The hazard ratios reflected that no treatment and unknown or non-standard treatments significantly increased mortality risks compared to the reference surgery group.<br /><br />The findings highlight the growing role of SBRT in treating older adults with early-stage SCLC and suggest it provides a viable non-surgical alternative with outcomes comparable to surgical interventions. The research underscores the necessity of tailored treatment strategies for the aging population, focusing on maximizing survival while considering treatment accessibility and individual patient profiles.

Asset Subtitle

Margaret Yang

Meta Tag

Speaker Margaret Yang

Topic SCLC & Neuroendocrine Tumors

Keywords

small cell lung cancer

SCLC

stage IA

elderly patients

treatment strategies

SBRT

surgery

survival outcomes

National Cancer Database

hazard ratios