2024 World Conference on Lung Cancer (WCLC) - Posters-P4.04D.05 Family History is an Independent Predictor of Lung Cancer Detection in Women in a Predominantly Caucasian Screening Cohort

P4.04D.05 Family History is an Independent Predictor of Lung Cancer Detection in Women in a Predominantly Caucasian Screening Cohort

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The study conducted by Xinxin Hu and colleagues investigates the role of family history (FHx) as an independent predictor of lung cancer detection in women within the International Lung Screen Trial (ILST). The trial, involving participants from Australia and Canada, evaluates the effectiveness of lung cancer screening using low-dose CT (LDCT) scans, primarily aimed at individuals with high-risk due to cigarette smoking.<br /><br />While cigarette smoking is a recognized risk factor and determinant for lung cancer screening eligibility, family history's role isn't typically included in eligibility criteria. This study specifically aims to assess the prevalence of family history in ILST participants and its association with lung cancer detection rates.<br /><br />The study's cohort consisted of 4,309 participants, of which 47% were female. Notably, 26% had a family history of lung cancer. Through a post-hoc analysis and logistic regression, the research determined the correlation between family history and increased lung cancer detection rates, with statistical significance set at p-value <0.05.<br /><br />Results of logistic regression modeling indicated that family history indeed predicts lung cancer detection independently in females. The statistical analysis showed a slight but consistent increase in lung cancer detection probability in individuals with a family history. Moreover, it was noted that female participants who had a family history of lung cancer demonstrated significantly less cigarette smoke exposure compared to those without a family history.<br /><br />Conclusively, the research underlines family history as an independent predictive factor of lung cancer in women participating in ILST. These findings suggest that family history should potentially be considered in lung cancer screening programs for more effective targeting and resource allocation, especially in national initiatives like the Australian National Lung Cancer Screening Program (NLCSP).

Asset Subtitle

Emily Stone

Meta Tag

Speaker Emily Stone

Topic Screening & Early Detection

Keywords

family history

lung cancer

International Lung Screen Trial

ILST

low-dose CT scans

cigarette smoking

lung cancer detection

logistic regression

female participants

Australian National Lung Cancer Screening Program