2024 World Conference on Lung Cancer (WCLC) - Posters-P4.07E.03 Real-World Data on Early Lung Cancer in Never-Smokers and Light Smokers-Prevalence, Family History, and Molecular Alterations

P4.07E.03 Real-World Data on Early Lung Cancer in Never-Smokers and Light Smokers-Prevalence, Family History, and Molecular Alterations

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The study conducted by the Department of Diagnostic, Molecular, and Interventional Radiology at the Icahn School of Medicine examines early-stage lung cancer in individuals who have never smoked or have smoked less than 20 pack-years. With the decline in smoking, this demographic's prevalence is rising, yet they are often excluded from lung cancer screening programs. The study, part of the Initiative for Early Lung Cancer Research on Treatment (IELCART), included 957 patients whose tumors were 30 mm or smaller. Among these, 37% were never smokers or light smokers.<br /><br />Key findings include that 18.4% of these patients had a family history of lung cancer, primarily involving first-degree relatives. Genetic analyses revealed that 64.1% of the patients had clinically actionable mutations, with EGFR mutations being the most common at 43.5%, particularly prevalent among Asian patients (66%). Other detected mutations were KRAS, MET, ROS1, RET, ALK, and BRAF, although less common.<br /><br />The significant portion of patients with molecular alterations suggests a distinct carcinogenic pathway for this group, which traditional screening protocols often overlook. The study underlines the necessity for targeted screening strategies and further research to better address lung cancer in never-smokers and light smokers.<br /><br />Overall, the study provides critical insights into the genetic and familial landscape of lung cancer in this specific population, highlighting the need for their inclusion in screening and early detection strategies.

Asset Subtitle

Louis Gros

Meta Tag

Speaker Louis Gros

Topic Early-Stage NSCLC

Keywords

early-stage lung cancer

never smokers

light smokers

lung cancer screening

genetic mutations

EGFR mutations

IELCART study

carcinogenic pathway

targeted screening

familial history