2024 World Conference on Lung Cancer (WCLC) - Posters-P4.07E.05 Insights from Molecular Profiling after Second Lung Surgeries in Early-Stage NSCLC

P4.07E.05 Insights from Molecular Profiling after Second Lung Surgeries in Early-Stage NSCLC - Recurrence or New Primary Tumor?

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The study investigates the genomic profiles of early-stage non-small cell lung cancer (NSCLC) patients who underwent second lung surgeries to discern whether the new tumors are recurrences or new primary tumors. The research, conducted as part of the Initiative for Early Lung Cancer Research on Treatment (IELCART), included 30 patients who had sequential surgical interventions along with genomic testing conducted between 2015 and 2022.<br /><br />The primary goal was to compare the genetic profiles of resected tumors from initial and subsequent surgeries within the same patient, and to assess the outcomes based on genomic concordance. The study utilized various genomic assays, initially with the Cancer Hotspot Panel v2 testing 50 cancer genes, later replaced by the Oncomine Comprehensive Assay v3 covering 161 genes.<br /><br />Key findings from this study include:<br />1. Among patients, there was a 53.3% genomic concordance rate between tumors in successive surgeries.<br />2. Tumors in the same lobe showed higher genomic similarity compared to those in different lobes, though this was not statistically significant (p=0.086).<br />3. The initial tumor size correlated significantly with concordance in subsequent tumors (p<0.05).<br />4. Clinical outcomes, such as recurrence rates, were comparable between cases with concordant and non-concordant genomic profiles.<br /><br />The study concludes that while within-lobe tumors tend to be genomically similar, there is a notable variance when tumors are located in different lobes. The findings indicate the need for better stipulated criteria for determining genomic concordance and underscore the importance of integrating clinical, pathological, and molecular features to enhance prediction and treatment strategies. Future investigations into next-generation sequencing may further illuminate these findings and refine these processes.

Asset Subtitle

Louis Gros

Meta Tag

Speaker Louis Gros

Topic Early-Stage NSCLC

Keywords

genomic profiles

non-small cell lung cancer

NSCLC

second lung surgeries

tumor recurrence

genomic concordance

Cancer Hotspot Panel

Oncomine Comprehensive Assay

genetic similarity

next-generation sequencing