2024 World Conference on Lung Cancer (WCLC) - Posters-P4.07G.01 Incidence of and Outcomes of Second Primary Lung Cancer after Resection for Screen-Detected Lung Cancer

P4.07G.01 Incidence of and Outcomes of Second Primary Lung Cancer after Resection for Screen-Detected Lung Cancer

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This study investigates the incidence and outcomes of second primary lung cancers (SPLC) in patients who underwent surgical resection for screen-detected initial primary lung cancer (IPLC), utilizing data from the National Lung Screening Trial (NLST). The focus is to understand both synchronous (occurring simultaneously with IPLC) and metachronous (occurring after an initial cancer) SPLC occurrences following surgery.<br /><br />The study included patients diagnosed with pathologic stage I IPLC detected via the NLST from 2002 to 2009, excluding those with non-malignant pathology. It evaluated the incidence rates of synchronous and metachronous SPLC, the 5-year cumulative incidence of metachronous SPLC, and survival outcomes, considering factors such as IPLC histology, smoking history, smoking status, and age.<br /><br />Key findings revealed that synchronous SPLC incidence was 3.0%, while the 5-year cumulative incidence for metachronous SPLC was 3.5%. It was observed that SPLC had differing stages at diagnosis and significantly varied long-term survival outcomes. Five-year overall survival for synchronous SPLC was 80.0%, whereas it was 53.9% for metachronous SPLC. Lung cancer-specific survival rates were 88.9% for synchronous and 61.5% for metachronous SPLC.<br /><br />The study highlights the importance of monitoring patients with resected screen-detected IPLC for secondary cancer occurrences. It provides valuable insights into the natural history and outcomes of SPLC after initial cancer resection, emphasizing the need for personalized follow-up strategies based on individual risk factors such as smoking history and cancer histology.

Asset Subtitle

Quiana Guo

Meta Tag

Speaker Quiana Guo

Topic Early-Stage NSCLC

Keywords

second primary lung cancer

SPLC

screen-detected lung cancer

surgical resection

National Lung Screening Trial

synchronous SPLC

metachronous SPLC

survival outcomes

smoking history

cancer histology