2024 World Conference on Lung Cancer (WCLC) - Posters-P4.07G.05 Prediction of Quality-of-Life Results after Lung Stereotactic Body Radiotherapy Using Functional Mapping on Gallium-68 Perfusion PET/CT

P4.07G.05 Prediction of Quality-of-Life Results after Lung Stereotactic Body Radiotherapy Using Functional Mapping on Gallium-68 Perfusion PET/CT

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The study led by Dr. François Lucia explores the use of Gallium-68 perfusion PET/CT imaging to personalize lung Stereotactic Body Radiotherapy (SBRT) and predict health-related quality-of-life (HRQoL) outcomes. Lung SBRT, known for its high local tumor control rates, can lead to radiation-induced lung toxicity, negatively impacting HRQoL. Traditional SBRT planning treats the lungs as functionally homogeneous, potentially overlooking regional differences in lung function.<br /><br />The research introduces a method called functional lung avoidance radiotherapy, where treatment plans are tailored to individual lung functional distributions. Gallium-68 perfusion PET/CT can enhance the accuracy of lung functional mapping, allowing for more precise treatment personalization aimed at reducing pulmonary toxicity.<br /><br />The PEGASUS trial, a single-center prospective study, investigates the HRQoL outcomes in patients receiving SBRT, examining dosimetric parameters as influential factors. It emphasizes the importance of mapping lung function using Gallium-68 instead of conventional 99mTc, noting the enhanced sensitivity and spatial resolution of PET technology. This innovation enables more effective functional lung avoidance planning.<br /><br />In the trial, 60 patients were included, with early and late HRQoL changes measured using EORTC QLQ-C30 and QLQ-LC13 questionnaires. The results indicated significant associations between increased radiation doses in functional lung volumes and decreased HRQoL, suggesting that functional planning might mitigate these effects more effectively than anatomical planning. <br /><br />The study concludes that functional lung avoidance guided by perfusion PET/CT is a promising noninvasive approach to enhance HRQoL in lung SBRT patients. The upcoming PEGASUS-2 trial aims to further explore this approach, comparing functional planning to traditional methods in a larger randomized, controlled setting.

Asset Subtitle

François Lucia

Meta Tag

Speaker François Lucia

Topic Early-Stage NSCLC

Keywords

Gallium-68

SBRT

lung toxicity

HRQoL

functional lung avoidance

PET/CT imaging

PEGASUS trial

radiotherapy

lung function mapping

radiation doses