2024 World Conference on Lung Cancer (WCLC) - Posters-P4.15D.02 Risk of Osteoporosis and Bone Fracture by Systemic Therapy in Lung Cancer Survivors

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This study evaluates the risk of osteoporosis and non-pathologic fractures in lung cancer survivors (LCS), focusing on the influence of systemic therapies, including chemotherapy, immunotherapy, and targeted therapy. Using diagnostic codes from TriNetX, researchers conducted a retrospective cohort study involving 474,352 adult LCS, excluding those with baseline bone conditions like metastases at diagnosis, pathological fractures, rheumatoid arthritis, or secondary malignancies.<br /><br />Participants were divided into groups based on the presence of metastases at diagnosis, and matched by demographics, nicotine use, and type of systemic therapy. The study aims to understand the impact of systemic therapies on the risks of osteoporosis and fractures among LCS, an aspect previously unreported specifically for lung cancer survivors.<br /><br />Key findings reveal that male LCS are less likely to develop osteoporosis or suffer fractures compared to females. LCS with metastases (LCS-M) are at an increased risk of both osteoporosis and non-pathologic fractures when compared to those without metastases (LCS-NM). Specifically, metastatic lung cancer survivors receiving targeted therapy face increased risks of both conditions. <br /><br />Chemotherapy was identified as a significant risk factor for developing osteoporosis, whereas targeted therapy showed a risk increase for both osteoporosis and fractures in metastatic cases. Nicotine use was associated with elevated risks for both osteoporosis and fractures. Surprisingly, immunotherapy did not show a significant impact on risk when compared to other therapies.<br /><br />Overall, this study highlights the heightened fracture and osteoporosis risks faced by lung cancer survivors, influenced by specific systemic therapies and nicotine use, with metastatic individuals being particularly vulnerable. This underscores the need for targeted bone health management strategies in this patient population.

Asset Subtitle

Melinda Hsu

Meta Tag

Speaker Melinda Hsu

Topic Multidisciplinary Care: Nursing, Allied Health & Palliative Care

Keywords

lung cancer survivors

osteoporosis risk

non-pathologic fractures

systemic therapies

chemotherapy

immunotherapy

targeted therapy

metastatic lung cancer

nicotine use

bone health management