2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.01A.01 Role of Diet and Exercise in Young Lung Cancer Patients with Driver Mutations (NCT04640259)

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The study titled "Role of Diet and Exercise in Young Lung Cancer Patients with Driver Mutations,” led by Jorge Nieva, MD, and other researchers, focuses on understanding lifestyle factors, specifically diet and exercise, in young lung cancer (YLC) patients with specific genetic mutations, such as ALK and EGFR. This research is a component of the Epidemiology of Young Lung Cancer Study (EoYLC), the largest epidemiological study of its kind, designed to investigate environmental, lifestyle, and genetic factors affecting young individuals diagnosed with lung cancer.<br /><br />Key preliminary findings suggest that patients with EGFR mutations are more likely to be older females with increased smoking exposure, lower body mass index (BMI), and differing usage of oral contraceptives and antihistamines, compared to their ALK counterparts. However, there's been limited information on dietary habits and physical activity patterns among these patients, which this report aims to address.<br /><br />The study enrolled 141 patients, categorized into ALK and EGFR groups, using a virtual, distributed clinical trial approach. Participants were assessed through the International Physical Activity Questionnaire (IPAQ) for exercise and a food frequency questionnaire for dietary habits. Results illustrate that both ALK and EGFR patient groups maintain healthier diets and higher physical activity levels compared to the average U.S. population. Despite variations in BMI and physical activity scores between the groups, overall, young lung cancer patients with these mutations exhibit a commendable focus on diet and exercise.<br /><br />The authors emphasize the need to further investigate the unique risk factors associated with different genomic subtypes of lung cancer. By disassociating these cancers from tobacco use, the study seeks to identify other environmental and biological elements contributing to this disease in young adults, thereby paving the way for more targeted epidemiological research.

Asset Subtitle

Jorge Nieva

Meta Tag

Speaker Jorge Nieva

Topic Risk Factors, Risk Reduction & Tobacco Control

Keywords

young lung cancer

driver mutations

diet and exercise

EGFR mutations

ALK mutations

Epidemiology of Young Lung Cancer Study

genetic factors

physical activity

dietary habits

Jorge Nieva