2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.01A.06 Characteristics of Non-Small Cell Lung Cancer with High Serum CEA Levels.

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The study by the Yamagata University Faculty of Medicine aims to evaluate characteristics of non-small cell lung cancer (NSCLC) patients with high levels of serum carcinoembryonic antigen (CEA), which is considered a poor prognostic factor after surgery. Conducted retrospectively using a prospectively collected database, the study included surgical cases spanning from April 2004 to March 2023, comparing patients with serum CEA levels of ≥10 ng/mL to those with lower levels.<br /><br />Key findings reveal that NSCLC patients with high serum CEA levels tend to be older, predominantly male, and more likely to have a history of smoking and respiratory comorbidities such as chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD). Furthermore, these patients are more likely to present with more advanced disease stages (II-IV) at diagnosis compared to those with lower CEA levels. The study also identifies a higher proportion of histological grade 3 (G3) adenocarcinomas, characterized by aggressive histological subtypes like solid and micropapillary adenocarcinoma, among patients with elevated CEA levels.<br /><br />The analysis involved both univariate and multivariate statistical methods, indicating that factors like smoking, age, and ILD are significantly associated with high serum CEA levels. The study also discusses discrepancies between serum CEA elevations due to neoplastic and some non-neoplastic conditions like smoking, though the former typically exceeds twice the normal cutoff value.<br /><br />In conclusion, the study underscores that NSCLC patients with elevated serum CEA are generally older, smokers, and have noticeable respiratory comorbidities, with a significant portion having aggressive adenocarcinomas (G3), drawing attention to the necessity for further research to understand the full implications of CEA in NSCLC prognosis and treatment planning.

Asset Subtitle

Kazumasa Hoshijima

Meta Tag

Speaker Kazumasa Hoshijima

Topic Risk Factors, Risk Reduction & Tobacco Control

Keywords

NSCLC

serum CEA

prognostic factor

Yamagata University

retrospective study

smoking history

respiratory comorbidities

adenocarcinoma

histological grade 3

multivariate analysis