2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.01D.01 Exploring the Association Between Connective Tissue Diseases and Lung Cancer: Analysis of the Mediating Role of Immune and Inflammatory Markers

EP.01D.01 Exploring the Association Between Connective Tissue Diseases and Lung Cancer: Analysis of the Mediating Role of Immune and Inflammatory Markers

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The study conducted by Yi Feng at the First Affiliated Hospital of Guangzhou Medical University systematically explores the potential link between connective tissue diseases (CTDs) and lung cancer, with a focus on the mediating role of immune and inflammatory markers. Previous research had suggested a possible increased risk of lung cancer in patients with certain CTDs, but this study aimed to provide a more comprehensive analysis.<br /><br />Utilizing data from the UK Biobank, the research involved 457,959 participants who did not have lung cancer at baseline. These individuals were observed over an average period of 9.21 years, during which 157,273 cases of CTDs and 4,229 cases of lung cancer were recorded. The median age of the participants was 57 years, and 54.20% were female.<br /><br />The study employed Cox proportional hazards models, adjusted for 14 covariates, to assess the risk of lung cancer in patients with CTDs. Additionally, mediation analysis was utilized to examine the relationship between thirteen CTDs linked to lung cancer and ten key immune and inflammatory markers. The results indicated that certain diseases, such as rheumatoid arthritis, gout, acquired deformities of fingers and toes, and systemic sclerosis, had stronger associations with lung cancer risk. These associations were predominantly mediated by factors like lymphocyte count, monocyte count, neutrophil to lymphocyte ratio, and systemic immune inflammation index.<br /><br />The findings conclude that while CTDs in general may not increase lung cancer risk, specific CTDs are significantly associated with higher risks. The impact of certain immune and inflammatory markers as mediators in this relationship provides valuable insights for the prevention and treatment strategies for both CTDs and lung cancer. This study highlights the importance of understanding underlying biological mechanisms to improve patient outcomes.

Asset Subtitle

Yi Feng

Meta Tag

Speaker Yi Feng

Topic Risk Factors, Risk Reduction & Tobacco Control

Keywords

connective tissue diseases

lung cancer

immune markers

inflammatory markers

UK Biobank

Cox proportional hazards

mediation analysis

rheumatoid arthritis

systemic sclerosis

biological mechanisms